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Evolution of the carboxylate Jen transporters in fungi.

Authors
  • Lodi, Tiziana1
  • Diffels, Julie
  • Goffeau, André
  • Baret, Philippe V
  • 1 Dipartimento di Genetica Biologia dei Microrganismi Antropologia Evoluzione, Università di Parma, Parma, Italy. [email protected] , (Italy)
Type
Published Article
Journal
FEMS yeast research
Publication Date
Aug 01, 2007
Volume
7
Issue
5
Pages
646–656
Identifiers
PMID: 17498214
Source
Medline
Language
English
License
Unknown

Abstract

Synteny analysis is combined with sequence similarity and motif identification to trace the evolution of the putative monocarboxylate (lactate/pyruvate) transporters Jen1p and the dicarboxylate (succinate/fumarate/malate) transporters Jen2p in Hemiascomycetes yeasts and Euascomycetes fungi. It is concluded that a precursor form of Jen1p, named here preJen1p, arose by the duplication of an ancestral Jen2p, during the speciation of Yarrowia lipolytica, which was transferred into a new syntenic context. The Jen1p transporters differentiated from preJen1p in Kluyveromyces lactis, before the Whole Genome Duplication (WGD), and are conserved as a single copy in the Saccharomyces species. In contrast, the ancestral Jen2p was definitively lost just prior to the WGD and is absent in Saccharomyces.

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