Affordable Access

Access to the full text

Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants

Authors
  • Ingle, Danielle J.1, 2, 3
  • Tauschek, Marija1
  • Edwards, David J.2, 3
  • Hocking, Dianna M.1
  • Pickard, Derek J.4
  • Azzopardi, Kristy I.1
  • Amarasena, Thakshila1
  • Bennett-Wood, Vicki1
  • Pearson, Jaclyn S.1
  • Tamboura, Boubou5
  • Antonio, Martin6
  • Ochieng, John B.7
  • Oundo, Joseph7
  • Mandomando, Inácio8, 9
  • Qureshi, Shahida10
  • Ramamurthy, Thandavarayan11
  • Hossain, Anowar12
  • Kotloff, Karen L.13
  • Nataro, James P.14
  • Dougan, Gordon4
  • And 3 more
  • 1 The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia , (Australia)
  • 2 Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010, Australia , (Australia)
  • 3 Centre for Systems Genomics, The University of Melbourne, Parkville, Victoria, 3010, Australia , (Australia)
  • 4 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK , Hinxton (United Kingdom)
  • 5 Centre pour le Développement des Vaccins du Mali, Bamako, Mali , (Mali)
  • 6 Medical Research Council Unit (United Kingdom), Fajara, The Gambia
  • 7 Kenya Medical Research Institute/Centers for Disease Control and Prevention, Kisumu, Kenya , (Kenya)
  • 8 Centro de Investigação em Saúde de Manhiça, (CISM), CP 1929, Maputo, Mozambique , (Mozambique)
  • 9 Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique , (Mozambique)
  • 10 The Aga Khan University, Karachi 74800, Pakistan , (Pakistan)
  • 11 National Institute of Cholera and Enteric Diseases, Kolkata, West Bengal, 700010, India , Kolkata (India)
  • 12 International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka, Bangladesh , (Bangladesh)
  • 13 Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA , Baltimore (United States)
  • 14 University of Virginia School of Medicine, Charlottesville, Virginia, 22908, USA , Charlottesville (United States)
  • 15 Murdoch Childrens Research Institute, Royal Children's Hospital, Victoria, 3052, Australia , (Australia)
Type
Published Article
Journal
Nature Microbiology
Publisher
Nature Publishing Group UK
Publication Date
Jan 18, 2016
Volume
1
Issue
2
Identifiers
DOI: 10.1038/nmicrobiol.2015.10
Source
Springer Nature
License
Yellow

Abstract

Whole genomes of 185 atypical enteropathogenic Escherichia coli (aEPEC) isolates reveal 30 LEE (locus of enterocyte effacement) subtypes in 3 major lineages, varying in insertion site preference and their complement of non-LEE encoded effector genes.

Report this publication

Statistics

Seen <100 times