Affordable Access

Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22.

Authors
  • Wang, S
  • Sun, C E
  • Walczak, C A
  • Ziegle, J S
  • Kipps, B R
  • Goldin, L R
  • Diehl, S R
Type
Published Article
Journal
Nature genetics
Publication Date
May 01, 1995
Volume
10
Issue
1
Pages
41–46
Identifiers
PMID: 7647789
Source
Medline
License
Unknown

Abstract

We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P = 2.3 x 10(-5)) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5-8%. The nonparametric affected pedigree member test provided results (P = 3 x 10(-4)) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia on distal chromosome 6p, and support a model of locus heterogeneity.

Report this publication

Statistics

Seen <100 times