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Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation.

Authors
  • Gonçalves, Isabel
  • Edsfeldt, Andreas
  • Ko, Na Young
  • Grufman, Helena
  • Berg, Katarina
  • Björkbacka, Harry
  • Nitulescu, Mihaela
  • Persson, Ana
  • Nilsson, Marie
  • Prehn, Cornelia
  • Adamski, Jerzy
  • Nilsson, Jan
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Jun 01, 2012
Volume
32
Issue
6
Pages
1505–1512
Identifiers
DOI: 10.1161/ATVBAHA.112.249854
PMID: 22499993
Source
Medline
License
Unknown

Abstract

The associations among Lp-PLA2, lysoPCs, LPA, and proinflammatory cytokines in human plaques suggest that lysoPCs play a key role in plaque inflammation and vulnerability. Our findings support Lp-PLA2 inhibition as a possible strategy for the prevention of cardiovascular disease.

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