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Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation.

Authors
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
1524-4636
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
32
Issue
6
Pages
1505–1512
Identifiers
DOI: 10.1161/ATVBAHA.112.249854
PMID: 22499993
Source
Medline
License
Unknown

Abstract

The associations among Lp-PLA2, lysoPCs, LPA, and proinflammatory cytokines in human plaques suggest that lysoPCs play a key role in plaque inflammation and vulnerability. Our findings support Lp-PLA2 inhibition as a possible strategy for the prevention of cardiovascular disease.

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