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Evidence for a polyclonal etiology of palmar fibromatosis.

Authors
  • Chansky, H A
  • Trumble, T E
  • Conrad, E U 3rd
  • Wolff, J F
  • Murray, L W
  • Raskind, W H
Type
Published Article
Journal
The Journal of hand surgery
Publication Date
Mar 01, 1999
Volume
24
Issue
2
Pages
339–344
Identifiers
PMID: 10194020
Source
Medline
License
Unknown

Abstract

X chromosome inactivation patterns at the androgen receptor locus were evaluated to determine clonality in microdissected lesional tissue and in leukocytes from 2 women with Dupuytren's disease. The tissue from both patients generated a polyclonal pattern of X chromosome inactivation of the human androgen receptor gene. This finding supports a polyclonal reactive process as the underlying etiology for palmar fibromatosis.

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