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Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus.

Authors
  • Richmond, J Y
Type
Published Article
Journal
Infection and immunity
Publication Date
Jun 01, 1977
Volume
16
Issue
3
Pages
827–831
Identifiers
PMID: 197007
Source
Medline
License
Unknown

Abstract

Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not covariant expressions of the same locus, but were under the control of different genes.

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