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Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain.

Authors
Type
Published Article
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
225
Issue
2
Pages
73–76
Identifiers
PMID: 9147377
Source
Medline
License
Unknown

Abstract

Acute phase serum amyloid A (A-apoSAA), but not constitutive apoSAA (C-apoSAA), was identified by Western blotting experiments in brain protein extracts from eight of nine patients with Alzheimer's disease (AD), one with a brain tumor and one with multiple sclerosis. A-apoSAA was not detected in six subjects with Pick's or Lewy Body disease or three other non-AD brain specimens. Apolipoprotein A-I and albumin were not found in any of the brain protein extracts. A-apoSAA mRNA was detected in AD brain by reverse transcription-polymerase chain reaction (RT-PCR). These data suggest that apoSAA is locally produced in AD brain and that investigation of the neuroinflammatory effects of this injury specific apolipoprotein is warranted.

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