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Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.

Authors
  • Richardson, B
  • Scheinbart, L
  • Strahler, J
  • Gross, L
  • Hanash, S
  • Johnson, M
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Nov 01, 1990
Volume
33
Issue
11
Pages
1665–1673
Identifiers
PMID: 2242063
Source
Medline
License
Unknown

Abstract

Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease.

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