Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.
- Published Article
Arthritis and rheumatism
- Publication Date
Nov 01, 1990
Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2242063