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Evidence for two T-helper populations with distinct specificity in the humoral response to influenza A viruses.

Authors
  • D B Thomas
  • C J Hackett
  • B A Askonas
Publication Date
Nov 01, 1982
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Virus specificity of T-helper cells for the humoral antibody response to influenza A viruses was studied with a hapten-carrier secondary adoptive transfer system, using whole virus, or viral components inserted into liposomes as carrier with B cells primed to DNP human gamma globulin. Evidence was obtained for two distinct T-helper cell populations from mice primed by influenza infection: a T-helper cell cross-reactive for all type A influenza viruses and a second T-helper population specific for the variant haemagglutinin. In vivo the virus cross-reactive T helpers recognized whole virus, but did not recognize isolated surface glycoproteins or internal virus proteins.

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