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Evidence for icaADBC-Independent Biofilm Development Mechanism in Methicillin-Resistant Staphylococcus aureus Clinical Isolates

Authors
  • Fidelma Fitzpatrick
  • Hilary Humphreys
  • James P. O'Gara
Publisher
American Society for Microbiology
Publication Date
Apr 01, 2005
Source
PMC
Keywords
Disciplines
  • Biology
  • Ecology
  • Geography
  • Philosophy
License
Unknown

Abstract

Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.

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