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Evidence for Balancing Selection at Hla

Authors
  • Philip W. Hedrick
  • Glenys Thomson
Publication Date
Jul 01, 1983
Source
PMC
Keywords
License
Unknown

Abstract

HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.

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