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Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine induced sera

Authors
  • Zhou, Daming1
  • Dejnirattisai, Wanwisa2
  • Supasa, Piyada2
  • Liu, Chang2, 3
  • Mentzer, Alexander J.2, 4
  • Ginn, Helen M.1
  • Zhao, Yuguang1
  • Duyvesteyn, Helen M.E.1
  • Tuekprakhon, Aekkachai2
  • Nutalai, Rungtiwa2
  • Wang, Beibei2
  • Paesen, Guido C.1
  • Lopez-Camacho, Cesar2
  • Slon-Campos, Jose2
  • Hallis, Bassam5
  • Coombes, Naomi5
  • Bewley, Kevin5
  • Charlton, Sue5
  • Walter, Thomas S.2
  • Skelly, Donal4, 6, 7
  • And 24 more
  • 1 Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The, Wellcome Centre for Human Genetics, Oxford, UK
  • 2 Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • 3 Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
  • 4 Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  • 5 National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK
  • 6 Peter Medawar Building for Pathogen Research, Oxford, UK
  • 7 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
  • 8 Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • 9 NIHR Oxford Biomedical Research Centre, Oxford, UK
  • 10 Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
  • 11 Worthing Hospital, Worthing, UK
  • 12 MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
  • 13 Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • 14 Sir William Dunn School of Pathology University of Oxford, Oxford, UK
  • 15 Translational Gastroenterology Unit, University of Oxford, Oxford, UK
  • 16 Centre For Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • 17 Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand. Department of Medicine, University of Oxford, Oxford, UK
  • 18 Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
  • 19 Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK
  • 20 Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK
Type
Published Article
Journal
Cell
Publisher
The Author(s). Published by Elsevier Inc.
Publication Date
Feb 23, 2021
Identifiers
DOI: 10.1016/j.cell.2021.02.037
PMCID: PMC7901269
Source
PubMed Central
License
Unknown

Abstract

Structure-function analysis of the SARS-CoV-2 variant B.1.351 using serum samples from convalescent and vaccinated individuals reveals how mutations in the viral spike protein result in tighter binding to the receptor ACE2 and allow escape from monoclonal antibody neutralization.

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