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Evidence for direct linkage between antigen recognition and lytic expression in effector T cells.

Authors
  • Kuppers, R C
  • Henney, C S
Type
Published Article
Journal
The Journal of experimental medicine
Publication Date
Mar 01, 1976
Volume
143
Issue
3
Pages
684–689
Identifiers
PMID: 1082495
Source
Medline
License
Unknown

Abstract

The relationship between antigen recognition and lytic expression by effector T cells was examined by coculturing two cytolytically active lymphoid cell populations. When antigen recognition between the populations could occur only in one direction, then cytotoxicity was expressed only in that direction and the population whose antigens were recognized lost its lytic activity. In contrast, the cocultured effector cell population fully maintained its lytic potential. This lack of reciprocal inactivation was taken as evidence that T-cell receptor accomodation by surface antigen is linked to the expression of cytolytic activity by effector T lymphocytes.

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