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Evidence of direct interaction between actin and membrane lipids.

Authors
  • St-Onge, D
  • Gicquaud, C
Type
Published Article
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
Publication Date
Jun 01, 1989
Volume
67
Issue
6
Pages
297–300
Identifiers
PMID: 2775532
Source
Medline
License
Unknown

Abstract

Actin is a protein component of the cystoskeleton and is involved in cell motility. It is believed generally that actin filaments are attached to the cell membrane through an interaction with membranous actin-binding proteins. By using an in vitro system composed of liposomes and actin, we have shown that actin may also interact directly with the phospholipids of the membrane. Actin deposited at the surface of the liposome is organized in two regular patterns: a paracrystalline sheet of parallel filaments in register, or a netlike organization. These interactions of actin with membrane lipids occur only in the presence of millimolar concentrations of Mg2+. These results suggest that the interaction of the cytoskeleton with the membrane involves, at least in part, a direct association of actin with phospholipids.

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