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Evidence for a central component in the cardiovascular effects of calcium channel blockers.

Authors
Type
Published Article
Journal
Journal of Cardiovascular Pharmacology
0160-2446
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
17
Issue
6
Pages
1015–1018
Identifiers
PMID: 1714005
Source
Medline
License
Unknown

Abstract

The possibility of a central component in the cardiovascular effects of peripherally administered calcium channel blockers has been explored through a comparison of the effects observed after intravenous (i.v.) and intracisternal (i.c.) administration of verapamil and diltiazem in chloralose-anesthetized and artificially ventilated cats. Both agents produced relatively greater effects after i.c. than after i.v. administration. The bradycardiac effect following i.c. as well as i.v. administration was totally abolished by bilateral cervical vagotomy, and the hypotensive effect was attenuated by this procedure. The results strongly suggest the existence of a central component in the cardiovascular effects of both agents.

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