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Evidence for brainstem structures participating in oculomotor integration.

Authors
  • Nakamagoe, K
  • Iwamoto, Y
  • Yoshida, K
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
May 05, 2000
Volume
288
Issue
5467
Pages
857–859
Identifiers
PMID: 10797008
Source
Medline
License
Unknown

Abstract

The cerebellar flocculus has been implicated in vestibulo-oculomotor control. One major central input to this structure originates from brainstem cells in the paramedian tract (PMT), whose function is unknown. Here it is reported that PMT cells in the pons carry vestibular and eye movement signals and their pharmacological inactivation produces a leaky integrator combined with vestibular imbalance. The results suggest that PMT cells provide the cerebellum with sensory and motor signals that are essential for velocity-to-position integration, a common premotor process that is required in all motor systems.

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