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Evidence for both in vivo and in vitro interaction between vigabatrin and alanine transaminase.

Authors
  • Richens, A
  • McEwan, J R
  • Deybach, J C
  • Mumford, J P
Type
Published Article
Journal
British journal of clinical pharmacology
Publication Date
Feb 01, 1997
Volume
43
Issue
2
Pages
163–168
Identifiers
PMID: 9131948
Source
Medline
License
Unknown

Abstract

The clinical significance of these findings is that the levels of ALA-T activity determined in patients receiving vigabatrin may be inaccurate. The "real' values must be assumed to be higher than those reported after routine testing. To obtain the most relistic measurement of ALA-T activity in patiets, samples should be taken at the times of trough plasma concentration and processed as soon as possible afterwards. Samples stored for any length of time at or above room temperature may also give even more false results.

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