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Evidence for a behavioral deficit during withdrawal from chronic nicotine treatment.

Authors
  • Corrigall, W A
  • Herling, S
  • Coen, K M
Type
Published Article
Journal
Pharmacology Biochemistry and Behavior
Publisher
Elsevier
Publication Date
Jul 01, 1989
Volume
33
Issue
3
Pages
559–562
Identifiers
PMID: 2587598
Source
Medline
License
Unknown

Abstract

Rats that had been trained to respond for food on a fixed-interval 3-minute schedule were treated once daily with nicotine (2 mg/kg) for 50 days. Animals developed marked tolerance to the depressant effect of nicotine as measured by the decreased effect of the treatment dose on response rates over days. Substitution of saline for nicotine during chronic treatment resulted in response rates which were significantly less than pretreatment values. In addition, following cessation of chronic treatment, response rates were initially suppressed below pretreatment rates; by the third day of withdrawal, response rates had returned to baseline levels. It is proposed that the response deficit observed during nicotine absence represents one behavioral component of a nicotine withdrawal syndrome.

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