Affordable Access

No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study.

Authors
  • Falkai, P
  • Honer, W G
  • David, S
  • Bogerts, B
  • Majtenyi, C
  • Bayer, T A
Type
Published Article
Journal
Neuropathology and applied neurobiology
Publication Date
Feb 01, 1999
Volume
25
Issue
1
Pages
48–53
Identifiers
PMID: 10194775
Source
Medline
License
Unknown

Abstract

Schizophrenia is clinically and neuropsychologically characterized by severe cognitive and functional impairment suggesting the presence of a neurodegenerative process in the brains of affected individuals. A variety of neuroanatomical changes have been described such as loss and disorientation of neurons in grey and white matter and cortical atrophy. However, the neuropathological basis for schizophrenia is still unclear. In the present study we monitored the density of GFAP-positive astrocytes in brains of 33 schizophrenic patients and 26 healthy controls. Both grey matter (entorhinal cortex and subiculum) and white matter (premotor cortex, subventricular zone of the third ventricle and next to inferior horn) structures were measured bilaterally. The overall finding was that there is no evidence for increased astrogliosis in brains of schizophrenic patients vs healthy controls. Therefore, degeneration is unlikely to be the main neuropathological mechanism in schizophrenic brains.

Report this publication

Statistics

Seen <100 times