Affordable Access

deepdyve-link
Publisher Website

Evidence of an age-related correlation of ovarian reserve and FMR1 repeat number among women with "normal" CGG repeat status.

Authors
  • Gustin, Stephanie L F1
  • Ding, Victoria Y2
  • Desai, Manisha2
  • Leader, Benjamin3
  • Baker, Valerie L4
  • 1 Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University School of Medicine, 900 Welch Road, Suite 20, Palo Alto, CA, 94034, USA. [email protected]
  • 2 Quantitative Sciences Unit, Center for Biomedical Informatics Research, Stanford University School of Medicine, 1070 Arastradero Road, Palo Alto, CA, 94304, USA.
  • 3 Clinical Research Division, ReproSource, Inc, 300 Tradecenter, Suite 6540, Woburn, MA, 01801, USA.
  • 4 Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University School of Medicine, 900 Welch Road, Suite 20, Palo Alto, CA, 94034, USA.
Type
Published Article
Journal
Journal of Assisted Reproduction and Genetics
Publisher
Springer-Verlag
Publication Date
Nov 01, 2015
Volume
32
Issue
11
Pages
1669–1676
Identifiers
DOI: 10.1007/s10815-015-0577-0
PMID: 26409477
Source
Medline
Keywords
License
Unknown

Abstract

This is the first study to report a statistically significant correlation of ovarian reserve and CGG repeat number in women with <55 CGG repeats. Although these women are generally considered to have a normal phenotype, our data suggest that increasing CGG repeat number within this normal range is associated with a more rapid decline in ovarian reserve.

Report this publication

Statistics

Seen <100 times