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Evidence for 12-lipoxygenase induction in the vessel wall following balloon injury.

Authors
Type
Published Article
Journal
Cardiovascular research
Publication Date
Volume
41
Issue
2
Pages
489–499
Identifiers
PMID: 10341849
Source
Medline
License
Unknown

Abstract

These results indicate for the first time that balloon injury results in marked induction of 12-LO mRNA and protein expression in the vessel wall. Furthermore, LO pathway activation may mediate, at least in part, the development of the lesion or plaque instability, suggesting a novel target for therapeutic intervention to block these pathological events.

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