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Event-related evoked potential versus clinical tests in assessment of subclinical cognitive impairment in chronic hepatitis C virus

  • Fath-Elbab, Hanaa Khalaf1
  • Ahmed, Elham1
  • Mansour, Dina Fathy1
  • Soliman, Wail Talaat1
  • 1 Minia University Faculty of Medicine, Minia, Egypt , Minia (Egypt)
Published Article
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Springer Berlin Heidelberg
Publication Date
Nov 20, 2018
DOI: 10.1186/s41983-018-0034-y
Springer Nature


ContextChronic infection by hepatitis C virus causes impairment in neurocognitive function in up to 50% of patients which may not be detected by clinical tests.AimEarly detection of neurocognitive impairment in chronic hepatitis C patients and investigating the cognitive function in HCV patient by p300 and clinical test.Materials and methodsThe study included 60 patients with chronic hepatitis C and 30 healthy controls. Participants were subjected to a biochemical, hematological assessment, mini-mental state examination, Montreal Cognitive Assessment, P300, polymerase chain reaction (PCR), and fibroscan made for hepatitis C patients.ResultsThe digit span, attention, concentration, and memory were significantly lower in patients than controls. The delayed P300 peak latency and the reduction of its amplitude were significantly evident in patients with liver fibrosis than the controls and patients without fibrosis. These abnormalities were significantly higher with increasing the grade of fibrosis. All patients with cognitive impairment (reduced mini-mental state score) had abnormal P300-evoked responses. P300 could detect neurocognitive impairment in some patients with normal neurocognitive functions by clinical test. P300 had sensitivity (100%), specificity (59.26), positive predictive value (75%), negative predictive value (100%), and accuracy (81.67) in the detection of neurocognitive impairment in HCV patient.ConclusionPatients with chronic hepatitis C infection had significant impairment in their cognitive functions. This impairment increases with the increase in grade of hepatic fibrosis. P300 can detect minimal and subclinical impairment of cognitive function at early stages of chronic hepatitis with accuracy (81.67).Trial registrationPACTR on 19 march 2018 retrospectively. Identification number for the registry is PACTR201804003215168.

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