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Evaluation of vitamin K3 feed additive for prevention of sweet clover disease.

Authors
  • Casper, H H1
  • Alstad, A D
  • Tacke, D B
  • Johnson, L J
  • Lloyd, W E
  • 1 Department of Veterinary Science, North Dakota State University, Fargo 58105.
Type
Published Article
Journal
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Publication Date
Apr 01, 1989
Volume
1
Issue
2
Pages
116–119
Identifiers
PMID: 2484931
Source
Medline
Language
English
License
Unknown

Abstract

Sweet clover poisoning in cattle is caused by an anticoagulant (dicumarol) that is formed in moldy sweet clover hay. Previous experiments with vitamin K3 and vitamin K1 in therapy trials indicated that vitamin K1 was effective in reducing prothrombin times but vitamin K3 was not. As a possible alternative in the use of toxic sweet clover hays, vitamin K3 was evaluated to see if it would prevent hemorrhagic crises when fed to cattle consuming toxic sweet clover hay. Vitamin K3 levels of 0, 0.45, 4.5, 11, and 45 mg/kg body weight/day were fed to 173-235-kg steers consuming toxic (40-50 ppm dicumarol) sweet clover. The 45-mg K3/kg/day supplement was not palatable and had to be discontinued. The 0.45, 4.5, and 11-mg K3/kg/day supplements did not significantly reduce the prothrombin times as compared to the 0-mg K3/kg/day group.

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