Affordable Access

deepdyve-link
Publisher Website

Evaluation of urine output, lactate levels and lactate clearance in the transitional period in very low birth weight preterm infants.

Authors
  • Junior, Luis Kanhiti Oharomari1
  • Carmona, Fabio2
  • Aragon, Davi Casale2
  • Gonçalves-Ferri, Walusa Assad3, 4
  • 1 Clinics Hospital of Ribeirao Preto, University of Sao Paulo, São Paulo, Brazil. , (Brazil)
  • 2 Ribeirao Preto Medical School, University of Sao Paulo, São Paulo, Brazil. , (Brazil)
  • 3 Ribeirao Preto Medical School, University of Sao Paulo, São Paulo, Brazil. [email protected] , (Brazil)
  • 4 Department of Pediatrics, Ribeirao Preto Medical School, Avenida dos Bandeirantes S/N, Campus Universitario, Ribeirao Preto, SP, 14049-900, Brazil. [email protected] , (Brazil)
Type
Published Article
Journal
European Journal of Pediatrics
Publisher
Springer-Verlag
Publication Date
Jan 01, 2021
Volume
180
Issue
1
Pages
91–97
Identifiers
DOI: 10.1007/s00431-020-03717-1
PMID: 32556457
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To assess the association between urine output (UO), arterial lactate levels (LL) and lactate clearance with haemodynamic instability and death in very low birth weight (VLBW) preterm in the transitional period. Retrospective cohort study with VLBW newborns born in 2016 and 2017, excluding those with malformations and without data. We evaluated 254 preterm infants with a total of 482 lactate levels measured in the first 72 h. Areas under the curve (AUC) were calculated for receiver-operator characteristics (ROC) curves of UO and LL (alone and combined) and of lactate clearance for prediction of haemodynamic instability and death. All AUC were below 0.80. Sensitivity and specificity were also not very good. Although patients with poor outcomes had lactate levels higher than those with good outcomes, discrimination was poor. UO and LL and lactate clearance were not good predictors of haemodynamic instability or death within 10 days of life. What is Known • It is already established that blood pressure is not a good marker for haemodynamic stability in the preterm infant. • Others clinical parameters, albeit are largely used, are not fully reliable as well. What is New • In our study we tried to determine the sensibility and specificity of urine output and arterial lactate and also the lactate clearance. • All AUC were below 0.80. Sensitivity and specificity were also not very good. Although patients with poor outcomes had lactate levels higher than those with good outcomes, discrimination was poor.

Report this publication

Statistics

Seen <100 times