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Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy.

  • Prahl, Mary
  • Golan, Yarden
  • Cassidy, Arianna G
  • Matsui, Yusuke
  • Li, Lin
  • Alvarenga, Bonny
  • Chen, Hao
  • Jigmeddagva, Unurzul
  • Lin, Christine Y
  • Gonzalez, Veronica J
  • Chidboy, Megan A
  • Warrier, Lakshmi
  • Buarpung, Sirirak
  • Murtha, Amy P
  • Flaherman, Valerie J
  • Greene, Warner C
  • Wu, Alan HB
  • Lynch, Kara L
  • Rajan, Jayant
  • Gaw, Stephanie L
Publication Date
Jul 01, 2022
eScholarship - University of California
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Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy.

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