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Evaluation of three immunochromatographic tests in COVID-19 serologic diagnosis and their clinical usefulness

Authors
  • Pegoraro, Manuela1
  • Militello, Valentina1
  • Salvagno, Gian Luca2
  • Gaino, Stefania2
  • Bassi, Antonella2
  • Caloi, Cecilia1
  • Peretti, Angelo1
  • Bizzego, Silvia1
  • Poletto, Laura1
  • Bovo, Chiara3
  • Lippi, Giuseppe2
  • Lo Cascio, Giuliana1
  • 1 Azienda Ospedaliera Universitaria Integrata Verona,
  • 2 University of Verona,
  • 3 University Hospital of Verona,
Type
Published Article
Journal
European Journal of Clinical Microbiology & Infectious Diseases
Publisher
Springer-Verlag
Publication Date
Oct 20, 2020
Pages
1–4
Identifiers
DOI: 10.1007/s10096-020-04040-1
PMID: 33078222
PMCID: PMC7572234
Source
PubMed Central
Keywords
License
Unknown

Abstract

Results of three rapid immunochromatographic tests (ICTs) were compared with those obtained with two automated immunoassays for evaluation of their usefulness. One hundred fifty-nine patients and 67 healthy volunteers were included. Different assays demonstrate 41–45% of diagnostic sensitivities and 91–98% of specificities, with substantial agreement (89.3–91.2%), but a high percentage of weak positive results (13–22%) was observed with ICTs. ICTs performances were comparable to those of automated immunoassays. ICTs could have a role as screening approach due to their easy usability. Subjective interpretation, significant rate of uncertain results, uncertainty on viral antigens source are undoubtedly drawbacks.

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