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Evaluation of three immunochromatographic tests in COVID-19 serologic diagnosis and their clinical usefulness.

Authors
  • Pegoraro, Manuela1
  • Militello, Valentina2
  • Salvagno, Gian Luca3
  • Gaino, Stefania3
  • Bassi, Antonella3
  • Caloi, Cecilia2
  • Peretti, Angelo2
  • Bizzego, Silvia2
  • Poletto, Laura2
  • Bovo, Chiara4
  • Lippi, Giuseppe3
  • Lo Cascio, Giuliana2
  • 1 Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy. [email protected] , (Italy)
  • 2 Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy. , (Italy)
  • 3 Section of Clinical Biochemistry, University of Verona, Verona, Italy. , (Italy)
  • 4 Medical Direction, University Hospital of Verona, Verona, Italy. , (Italy)
Type
Published Article
Journal
European Journal of Clinical Microbiology & Infectious Diseases
Publisher
Springer-Verlag
Publication Date
Oct 20, 2020
Identifiers
DOI: 10.1007/s10096-020-04040-1
PMID: 33078222
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Results of three rapid immunochromatographic tests (ICTs) were compared with those obtained with two automated immunoassays for evaluation of their usefulness. One hundred fifty-nine patients and 67 healthy volunteers were included. Different assays demonstrate 41-45% of diagnostic sensitivities and 91-98% of specificities, with substantial agreement (89.3-91.2%), but a high percentage of weak positive results (13-22%) was observed with ICTs. ICTs performances were comparable to those of automated immunoassays. ICTs could have a role as screening approach due to their easy usability. Subjective interpretation, significant rate of uncertain results, uncertainty on viral antigens source are undoubtedly drawbacks.

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