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Evaluation of the T helper 17 cell specific genes and the innate lymphoid cells counts in the peripheral blood of patients with the common variable immunodeficiency.

Authors
  • Ganjalikhani-Hakemi, Mazdak
  • Yazdani, Reza
  • Sherkat, Roya
  • Homayouni, Vida
  • Masjedi, Mohsen
  • Hosseini, Mohsen
Type
Published Article
Journal
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
Publication Date
Mar 01, 2014
Volume
19
Issue
Suppl 1
Identifiers
PMID: 25002891
Source
Medline
Keywords
License
Unknown

Abstract

The results presented in this study show that the Th17 cell specific genes expression (as the determiner Th17 cells) and ILCs (another lymphoid source of IL-17) are decreased in patients with CVID and this could be an explanation for the defect of their humoral immune response. In addition, elevation of the IL-9 gene expression may shed a new light into the way toward the understanding of the mechanism of autoimmunity in the CVID patients.

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