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Evaluation of the susceptibility test of polymyxin B using the commercial test Policimbac®.

Authors
  • Dalmolin, Tanise Vendruscolo1, 2
  • Carneiro, Maiara Dos Santos1, 2
  • de Castro, Luíza Peres1
  • Volpato, Fabiana Caroline Zempulski1, 3
  • Wink, Priscila Lamb1, 2
  • de Lima-Morales, Daiana1
  • Barth, Afonso Luís4, 5, 6
  • 1 Laboratório de Pesquisa em Resistência Bacteriana-LABRESIS, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. , (Brazil)
  • 2 Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. , (Brazil)
  • 3 Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. , (Brazil)
  • 4 Laboratório de Pesquisa em Resistência Bacteriana-LABRESIS, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. [email protected] , (Brazil)
  • 5 Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. [email protected] , (Brazil)
  • 6 Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. [email protected] , (Brazil)
Type
Published Article
Journal
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Publication Date
Sep 01, 2020
Volume
51
Issue
3
Pages
1135–1137
Identifiers
DOI: 10.1007/s42770-020-00246-9
PMID: 32198730
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Broth microdilution (BMD), the reference method to determine bacterial susceptibility to polymyxins, is a laborious and time-consuming technique. Policimbac® is a commercial test panel which uses lyophilized polymyxin B to determine the minimum inhibitory concentration for Gram-negative isolates. This study evaluated the performance of Policimbac® in comparison with BMD for 110 isolates. Although the Policimbac® presented a very low essential agreement, the categorical agreement with BMD was optimal. Policimbac® is an alternative approach to BMD for evaluating the susceptibility to polymyxin B.

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