Affordable Access

deepdyve-link
Publisher Website

Evaluation of short-term epigenetic age fluctuation

Authors
  • Komaki, Shohei
  • Ohmomo, Hideki
  • Hachiya, Tsuyoshi
  • Sutoh, Yoichi
  • Ono, Kanako
  • Furukawa, Ryohei
  • Umekage, So
  • Otsuka-Yamasaki, Yayoi
  • Minabe, Shiori
  • Takashima, Akira
  • Tanno, Kozo
  • Sasaki, Makoto
  • Shimizu, Atsushi
Type
Published Article
Journal
Clinical Epigenetics
Publisher
Springer-Verlag
Publication Date
Jun 09, 2022
Volume
14
Identifiers
DOI: 10.1186/s13148-022-01293-9
PMID: 35681206
PMCID: PMC9185970
Source
PubMed Central
Keywords
Disciplines
  • Brief Report
License
Unknown

Abstract

Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications. Supplementary Information The online version contains supplementary material available at 10.1186/s13148-022-01293-9.

Report this publication

Statistics

Seen <100 times