Evaluation of short-term epigenetic age fluctuation.

Shohei Komaki; Hideki Ohmomo; Tsuyoshi Hachiya; Yoichi Sutoh; Kanako Ono; Ryohei Furukawa; So Umekage; Yayoi Otsuka-Yamasaki; Shiori Minabe; Akira Takashima; Kozo Tanno; Makoto Sasaki; Atsushi Shimizu

doi:10.1186/s13148-022-01293-9

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Evaluation of short-term epigenetic age fluctuation.

Authors

Komaki, Shohei¹
Ohmomo, Hideki^{1, 2}
Hachiya, Tsuyoshi¹
Sutoh, Yoichi¹
Ono, Kanako¹
Furukawa, Ryohei^{1, 3}
Umekage, So¹
Otsuka-Yamasaki, Yayoi¹
Minabe, Shiori¹
Takashima, Akira¹
Tanno, Kozo^{4, 5}
Sasaki, Makoto^{6, 7}
Shimizu, Atsushi^{8, 9}

¹ Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, 1-1-1, Idaidori, Yahaba, Iwate, 028-3694, Japan. , (Japan)
² Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate, 028-3694, Japan. , (Japan)
³ Department of Biology, Research and Education Center for Natural Sciences, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa, 223-8521, Japan. , (Japan)
⁴ Division of Clinical Research and Epidemiology, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan. , (Japan)
⁵ Department of Hygiene and Preventive Medicine, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate, 028-3694, Japan. , (Japan)
⁶ Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan. , (Japan)
⁷ Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate, 028-3694, Japan. , (Japan)
⁸ Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, 1-1-1, Idaidori, Yahaba, Iwate, 028-3694, Japan. [email protected]. , (Japan)
⁹ Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate, 028-3694, Japan. [email protected]. , (Japan)

Type

Published Article

Journal

Clinical Epigenetics

Publisher

Springer-Verlag

Publication Date

Jun 09, 2022

Volume

14

Issue

1

Pages

76–76

Identifiers

DOI: 10.1186/s13148-022-01293-9

PMID: 35681206

Source

Medline

Keywords

Language

English

License

Unknown

Abstract

Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications. © 2022. The Author(s).

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 12/19/2022 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/35681206

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