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Evaluation of a sequential 5-FU and hydroxyurea combination in advanced bowel cancer.

Authors
  • Kao, A K
  • Muggia, F M
  • Dubin, N
  • Lerner, W A
  • Stark, R
  • Wernz, J C
  • Speyer, J L
  • Blum, R H
Type
Published Article
Journal
Cancer treatment reports
Publication Date
Nov 01, 1984
Volume
68
Issue
11
Pages
1383–1385
Identifiers
PMID: 6498854
Source
Medline
License
Unknown

Abstract

Twenty-nine patients (two with small bowel cancer and 27 with colorectal cancer) were treated with a sequential 5-FU-hydroxyurea combination following the suggestion of schedule-dependent synergism in experimental systems. No enhanced toxicity was observed, but the response rate was only 4%. Seven additional patients manifested greater than or equal to 50% declines in CEA, but caution must be used in interpreting such changes as antitumor activity.

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