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Evaluation of renal quantitative T2* changes on MRI following administration of ferumoxytol as a T2* contrast agent.

Authors
  • Hedgire, Sandeep S
  • McDermott, Shaunagh
  • Wojtkiewicz, Gregory R
  • Abtahi, Seyed Mahdi
  • Harisinghani, Mukesh
  • Gaglia, Jason L
Type
Published Article
Journal
International Journal of Nanomedicine
Publisher
Dove Medical Press
Publication Date
Jan 01, 2014
Volume
9
Pages
2101–2107
Identifiers
DOI: 10.2147/IJN.S61460
PMID: 24812510
Source
Medline
Keywords
License
Unknown

Abstract

There is significant and differential uptake of ferumoxytol in the cortex and medulla of physiologically normal kidneys. This differential uptake may offer the ability to interrogate renal cortex and medulla with possible clinical applications in medical renal disease and transplant organ assessment. We propose an organ of interest based dose titration of ferumoxytol to better differentiate circulating from intracellular ferumoxytol particles.

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