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Evaluation of the relationship between ventricular function and serum growth differentiation factor-15 levels in patients with operated tetralogy of Fallot.

Authors
  • Önal, Damla1
  • Eroğlu, Ayşe G1
  • Akyel, Nazlı G2
  • Yüksel, Esra K1
  • Karakaş, Hasan1
  • Pirdal, Betül Z3
  • Adaletli, İbrahim2
  • 1 İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Department of Pediatrics, İstanbul, Turkey. , (Turkey)
  • 2 İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Department of Radiology, Division of Pediatric Radiology, İstanbul, Turkey. , (Turkey)
  • 3 İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Department of Public Health, İstanbul, Turkey. , (Turkey)
Type
Published Article
Journal
Cardiology in the Young
Publisher
Cambridge University Press
Publication Date
Dec 01, 2021
Volume
31
Issue
12
Pages
1969–1974
Identifiers
DOI: 10.1017/S1047951121001360
PMID: 33827736
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Growth differentiation factor-15 is a novel biomarker of increasing importance in cardiovascular diseases. This study aimed to evaluate the relationship between ventricular measurements assessed by cardiac magnetic resonance imaging (MRI) and serum growth differentiation factor-15 levels in children with surgically corrected tetralogy of Fallot. Serum growth differentiation factor-15 levels were measured in 40 patients (mean age: 15.2 ± 2.9 years; 52.5% male; 87.5% NYHA I). End-diastolic volume index, end-systolic volume index, and ejection fractions of both ventricles and pulmonary regurgitation fraction were measured on cardiac MRI. The correlation between growth differentiation factor-15 levels and cardiac MRI parameters of the patients was investigated. Also, growth differentiation factor-15 levels of the patients were compared with healthy controls since reference values have not been determined in children. The mean growth differentiation factor-15 level was 254.9 ± 6.3 pg/ml in the patient group. There was no correlation between growth differentiation factor-15 levels and cardiac MRI parameters in patients. Also, there was no significant difference in growth differentiation factor-15 levels between the patients and control groups. The serum levels of growth differentiation factor-15 were uncorrelated with ventricular size, function, and pulmonary regurgitation fraction assessed by cardiac MRI in children with operated tetralogy of Fallot. Moreover, growth differentiation factor-15 levels were not different in these patients from healthy children.

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