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Evaluation of Regional Liver Function by Gadolinium-EOB-DTPA-Enhanced MR Imaging

Authors
  • Shimizu, Junzo
  • Dono, Keizo
  • Gotoh, Mitsukazu
  • Hasuike, Yasunori
  • Kim, Tonsok
  • Murakami, Takamichi
  • Sakon, Masato
  • Umeshita, Koji
  • Nagano, Hiroaki
  • Nakamori, Shoji
  • Kato, Naoki
  • Miyazawa, Tomoaki
  • Nakamura, Hironobu
  • Monden, Morito
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Jul 01, 1999
Volume
44
Issue
7
Pages
1330–1337
Identifiers
DOI: 10.1023/A:1026679113772
Source
Springer Nature
Keywords
License
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Abstract

We evaluated the role of magnetic resonance (MR)imaging withgadolinium-ethoxybenzyl-diethylenetriamine-pentaaceticacid (Gd-EOB-DTPA), in estimating regional liverfunction in a rat ischemia-reperfusion model. Ischemic liver damage was induced in theright lobe by vascular clamping for 0 (sham), 30 (I-30),60 (I-60), and 90 min (I-90 group). The ischemic lobesin the I-60 and I-90 groups was clearly visualized as a high intensity area in the T1 images atlate phase of Gd-EOB-DTPA enhancement, Moreover, the T1/2 of signal intensity in ischemic lobes significantlycorrelated with the duration of vascular clamping. We also observed significant correlationbetween T 1/2 and ATP concentration in the liver tissue(r = –0.719, P = 0.04). Our results indicate thatMR imaging with Gd-EOB-DTPA is useful for evaluation of regional liver function in rats.

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