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Evaluation of an enzyme immunoassay for serum gentamicin.

Authors
  • T D O'Leary
  • R M Ratcliff
  • T D Geary
Publication Date
May 01, 1980
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

The EMIT (Enzyme Multiplied Immunoassay Technique) for serum gentamicin determination was evaluated by a standard procedure. The precision, accuracy, and specificity were assessed and proved satisfactory. Comparison with a bioassay was done, and results for patient samples showed a correlation coefficient of 0.95 between the two methods. Advantages of the enzyme immunoassay system were the provision of results within 15 min of receipt of blood in the laboratory, a requirement of minimal technical expertise, and an applicability to both large and small workloads. The EMIT proved during evaluation to be a practical alternative to current bioassays for the determination of serum gentamicin concentrations.

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