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Evaluation of Macular Vascular Abnormalities Identified by Optical Coherence Tomography Angiography in Sickle Cell Disease.

Authors
  • Han, Ian C1
  • Tadarati, Mongkol1
  • Pacheco, Katia D1
  • Scott, Adrienne W2
  • 1 Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
  • 2 Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address: [email protected]
Type
Published Article
Journal
American journal of ophthalmology
Publication Date
May 01, 2017
Volume
177
Pages
90–99
Identifiers
DOI: 10.1016/j.ajo.2017.02.007
PMID: 28212878
Source
Medline
Language
English
License
Unknown

Abstract

To evaluate macular vascular flow abnormalities identified by optical coherence tomography angiography (OCT-A) in patients with various sickle cell genotypes. Prospective, observational case series. This is a single-institution case series of adult patients with various sickle cell genotypes. All patients underwent macular OCT-A (Avanti RTVue XR). Images were analyzed qualitatively for areas of flow loss and quantitatively for measures of foveal avascular area, parafoveal flow, and vascular density. The findings were compared by sickle cell genotype and retinopathy stage and correlated to retinal thickness and visual acuity. OCT-A scans of 82 eyes from 46 patients (60.9% female, mean age 33.5 years) were included. Sickle cell genotypes included 27 patients with hemoglobin SS (58.7%), 14 SC (30.4%), 4 beta-thalassemia (8.7%), and 1 sickle trait (2.2%). Discrete areas of flow loss were noted in 37.8% (31/82) of eyes overall and were common in both SS (40.0%, 20/50 eyes) and SC (41.7%, 10/24 eyes). Flow loss was more extensive in the temporal and nasal parafoveal subfields of the deep plexus with sickle SC or proliferative retinopathy. Retinal thickness measurements correlated with vascular density of the fovea, parafovea, and temporal and superior subfields. Visual acuity correlated with foveal avascular zone area and parafoveal vascular density in the superficial and deep plexi. Areas of abnormal macular vascular flow are common in patients with various sickle cell genotypes. These areas may be seen at any retinopathy stage but may be more extensive with sickle SC or proliferative retinopathy. Copyright © 2017 Elsevier Inc. All rights reserved.

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