Affordable Access

Access to the full text

Evaluation of lateral flow immunochromatographic assay for diagnostic accuracy of cryptococcosis

Authors
  • Xie, Li-Min1, 2
  • Lin, Geng-Ling1, 2
  • Dong, Hao-Neng1, 2
  • Liao, Ying-Xia1, 2
  • Liu, Ye-Ling1, 2
  • Qin, Jian-Feng3
  • Guo, Xu-Guang1, 2, 2, 2
  • 1 The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China , Guangzhou (China)
  • 2 The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China , Guangzhou (China)
  • 3 The Pharmic School of Guangzhou Medical University, Guangzhou, 511436, China , Guangzhou (China)
Type
Published Article
Journal
BMC Infectious Diseases
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Sep 04, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12879-020-05368-x
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundCryptococcus is a conditional pathogenic fungus causing cryptococcosis, which is one of the most serious fungal diseases faced by humans. Lateral flow immunochromatographic assay (LFA) is successfully applied to the rapid detection of cryptococcal antigens.MethodsStudies were retrieved systematically from the Embase, PubMed, Web of Science, and Cochrane Library before July 2019. The quality of the studies was assessed by Review Manager 5.0 based on the Quality Assessment of Diagnostic Accuracy Study guidelines. The extracted data from the included studies were analyzed by Meta-DiSc 1.4. Stata 12.0 software was used to detect the publication bias.ResultsA total of 15 articles with 31 fourfold tables were adopted by inclusion and exclusion criteria. The merged sensitivity and specificity in serum were 0.98 and 0.98, respectively, and those in the cerebrospinal fluid were 0.99 and 0.99, respectively.ConclusionsCompared to the urine and other samples, LFA in serum and cerebrospinal fluid is favorable evidence for the diagnosis of cryptococcosis with high specificity and sensitivity.

Report this publication

Statistics

Seen <100 times