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Evaluation of Ivermectin vs Permethrin for Treating Scabies-Summary of a Cochrane Review.

Authors
  • Rosumeck, Stefanie1
  • Nast, Alexander1
  • Dressler, Corinna1
  • 1 Division of Evidence-Based Medicine, Department of Dermatology, Venereology, and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. , (Germany)
Type
Published Article
Journal
JAMA dermatology
Publication Date
Jun 01, 2019
Volume
155
Issue
6
Pages
730–732
Identifiers
DOI: 10.1001/jamadermatol.2019.0279
PMID: 31017622
Source
Medline
Language
English
License
Unknown

Abstract

Is the use of ivermectin in patients infested with scabies associated with improved clinical and safety outcomes compared with permethrin? Both ivermectin and permethrin treatment were associated with high clearance rates. There is low-certainty evidence that ivermectin was associated with slightly lower rates of complete clearance after 1 week compared with permethrin, 5%, cream (relative risk [RR], 0.65; 95% CI, 0.54-0.78). After 2 weeks, there was no difference in efficacy (RR, 0.91; 95% CI, 0.76-1.08; low-certainty evidence), or in the number of participants with adverse events (week 4: RR, 1.30; 95% CI, 0.35-4.83; low-certainty evidence).

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