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Evaluation of intestinal permeability of vicenin-2 and lychnopholic acid from Lychnophora salicifolia (Brazilian arnicão) using Caco-2 cells.

Authors
  • Gouvea, Dayana Rubio
  • de Barros Bello Ribeiro, Arthur
  • Thormann, Ursula
  • Lopes, Norberto Peporine
  • Butterweck, Veronika
Type
Published Article
Journal
Journal of Natural Products
Publisher
American Chemical Society
Publication Date
Mar 28, 2014
Volume
77
Issue
3
Pages
464–471
Identifiers
DOI: 10.1021/np400674t
PMID: 24279746
Source
Medline
License
Unknown

Abstract

Lychnophora salicifolia, commonly known as "arnicão", is used as an anti-inflammatory agent and as a flavoring agent in the Brazilian traditional spirit "cachaça". In this work, the permeation process of vicenin-2 (1) and lychnopholic acid (2) (major secondary metabolites from the hydroalcoholic extract) was investigated using Caco-2 cells. For this investigation, a new HPLC-DAD method was developed and validated for the quantification step. It was observed that 2 crosses the Caco-2 cell monolayer by passive diffusion. On the other hand, 1 was not transported, suggesting no absorption and no efflux of this compound in Caco-2 cells.

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