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Evaluation of inpatients Clostridium difficile prevalence and risk factors in Cameroon

Authors
  • Djuikoue, Ingrid Cécile1, 2
  • Tambo, Ernest1, 2
  • Tazemda, Gildas1
  • Njajou, Omer2
  • Makoudjou, Denise1
  • Sokeng, Vanessa1
  • Wandji, Morelle1
  • Tomi, Charlène1
  • Nanfack, Aubain3
  • Dayomo, Audrey1
  • Lacmago, Suzie1
  • Tassadjo, Falubert4
  • Sipowo, Raissa Talla1
  • Kakam, Caroline3
  • Djoko, Aicha Bibiane1
  • Assob, Clement Nguedia5
  • Andremont, Antoine6
  • Barbut, Frédéric7
  • 1 Département de Microbiologie de la Faculté des Sciences de la Santé de l’Université des Montagnes, Bangangte, Cameroon , Bangangte (Cameroon)
  • 2 Prevention and Control Foundation, Bangangte, Cameroon , Bangangte (Cameroon)
  • 3 Medical Diagnostic Centerto Yaounde, Yaounde, Cameroon , Yaounde (Cameroon)
  • 4 Laboratoire de Bactériologie du Centre Pasteur du Cameroun, Yaounde, Cameroon , Yaounde (Cameroon)
  • 5 University of Buea, Buea, SW Region, Cameroon , Buea (Cameroon)
  • 6 University of Paris VII – Denis Diderot, Paris, France , Paris (France)
  • 7 Faculty of Pharmacy, Paris – University of Paris Descartes, Paris, France , Paris (France)
Type
Published Article
Journal
Infectious Diseases of Poverty
Publisher
BioMed Central
Publication Date
Aug 31, 2020
Volume
9
Issue
1
Identifiers
DOI: 10.1186/s40249-020-00738-8
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundClostridium difficile, rarely found in hospitals, is a bacterium responsible for post-antibiotic diarrhea and Pseudomembranous Colitis (CPM). C. difficile selective pressure represents potential public health problem due to the production of toxins A and B serious pathologies effects/consequences. A transversal and analytic study was to assess the risk factors of C. difficile infection and to determine the prevalence of C. difficile in patients received in randomly selected five hospitals in Yaoundé, Cameroon.MethodsA total of 300 stool samples were collected from consented patients using a transversal and analytic study conducted from 10th July to 10th November 2018 in five hospitals in Cameroon. The detection or diagnostic kit was CerTest C. difficile Glutamate Dehydrogenase + Toxin A + Toxin B based on immuno-chromatographic assay. A univariate and multivariate analysis allowed us to highlight the associated factors.ResultsThe results showed a prevalence of C. difficile of 27.33% (82/300 stool patients’samples taken). Of these 27.33%, the production of Toxin A and Toxin B were 37.80 and 7.31% respectively. In univariate analysis, hospitalization was a significant (P = 0.01) risk factor favoring C. difficile infection. In multivariate analysis, corticosteroids and quinolones use/administration were significantly (adjusted Odd Ratio, aOR = 14.09, 95% CI: 1.62–122.54, P = 0.02 and aOR = 3.39, 95% CI: 1.00–11.34, P = 0.05 respectively) risk factor for this infection.ConclusionThe prevalence of C. difficile infections (CDI) remain high in these settings and may be related not only to permanent steroids and antibiotics. Promoting education to both medical staff and patients on the prevalence and public health impact of C. difficile can be core inimproving rationale prescription of steroids and antibiotics to patients and promote human health and exponential growth in Cameroon.

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