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Evaluation of the induction of hepatic drug-metabolizing enzymes in the rat and mouse treated with temazepam using trimethadione as the indicator.

Authors
Type
Published Article
Journal
The Journal of toxicological sciences
Publication Date
Volume
10
Issue
1
Pages
21–28
Identifiers
PMID: 2862289
Source
Medline

Abstract

In the present paper we report the effect of high doses of temazepam on drug-metabolism induction in rat and mouse. Temazepam induced a dose-dependent and reversible increase of hepatic microsomal drug-metabolizing enzymes in the rat, dose-correlated increase of dimethadione/trimethadione ratios in plasma of the rat, and dose-related shortening of hexobarbital-induced sleeping time in the mouse. In this study trimethadione is considered a good indicator for estimating the state of hepatic enzyme induction.

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