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Evaluation of flavoglaucin, its derivatives and pyranonigrins produced by molds used in fermented foods for inhibiting tumor promotion.

Authors
  • Miyake, Yoshiaki
  • Ito, Chihiro
  • Tokuda, Harukuni
  • Osawa, Toshihiko
  • Itoigawa, Masataka
Type
Published Article
Journal
Bioscience Biotechnology and Biochemistry
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jan 01, 2010
Volume
74
Issue
5
Pages
1120–1122
Identifiers
PMID: 20460698
Source
Medline
License
Unknown

Abstract

Flavoglaucin, its derivatives, and pyranonigrins, which are antioxidants produced by the molds used in fermented foods, were examined for their inhibition of tumor promotion by the Epstein-Barr virus early antigen activation test. Flavoglaucin and its derivatives exhibited high activity. Flavoglaucin and such a derivative as isodihydroauroglaucin inhibited mouse skin tumor promotion in a two-stage carcinogenesis test and appear to be antitumor promoters.

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