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Evaluation of drug formulations using LD50 testing in mice.

Authors
  • Sheth, P R
  • Shah, N H
  • Pool, W
Type
Published Article
Journal
Journal of pharmaceutical sciences
Publication Date
Nov 01, 1977
Volume
66
Issue
11
Pages
1567–1570
Identifiers
PMID: 915733
Source
Medline
License
Unknown

Abstract

The LD50 values were utilized to assess the relative rate of absorption of two very poorly soluble drugs. Formulations of these drugs were studied by micronization; addition of surfactant, alkaline or buffering agents, and/or bile salts; coprecipitation; melt or fusion techniques; or granulation with hydrophilic agents. Differences in toxicities were demonstrated from formulations compared to pure drugs by the LD50 method. This study shows that the LD50 is a practical, rapid method of achieving comparative evaluations of drug formulations.

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