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Evaluation of CSF-adenosine deaminase activity in tubercular meningitis.

Authors
  • Gambhir, I S
  • Mehta, M
  • Singh, D S
  • Khanna, H D
Type
Published Article
Journal
The Journal of the Association of Physicians of India
Publication Date
Feb 01, 1999
Volume
47
Issue
2
Pages
192–194
Identifiers
PMID: 10999088
Source
Medline
License
Unknown

Abstract

Sixty patients of inflammatory brain disease were diagnosed and classified according to clinico-investigational criteria by Ahuja et al into tuberculous meningitis group (36 patients) and non-tuberculous meningitis group (24 patients). Tuberculous meningitis (TBM) patients were classified as probable (9 patients) and possible (27 patients) TBM. Non-TBM group comprised of pyogenic meningitis (8.3%), viral encephalitis (23.3%), cerebral malaria (5%) and enteric encephalopathy (3.3%). Cerebrospinal fluid-adenosine deaminase (CSF-ADA) activities were measured in both TBM and non-TBM groups. Mean CSF-ADA levels in TBM patients was 9.61 +/- 4.10 IU/L and was significantly elevated as compared to viral encephalitis and enteric encephalopathy cases; but difference was insignificant in comparison to pyogenic meningitis (7.92 +/- 0.95 IU/L) and cerebral malaria. Using 8 IU/L as cut off value for diagnosis of TBM a sensitivity of 44% and specificity of 75% was observed.

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