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Evaluation of bone healing activity of Cissus quadrangularis (Linn), Cryptolepis buchanani, and Sardinella longiceps in Wistar rats

Authors
  • Ramachandran, Somasundaram1
  • Fadhil, Laith1
  • Gopi, Chandravadivelu1
  • Amala, Masa1
  • Dhanaraju, Magharla Dasaratha1
  • 1 GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, 533296, India , Rajahmundry (India)
Type
Published Article
Journal
Beni-Suef University Journal of Basic and Applied Sciences
Publisher
Springer Berlin Heidelberg
Publication Date
May 01, 2021
Volume
10
Issue
1
Identifiers
DOI: 10.1186/s43088-021-00120-z
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThe object of the present study is to evaluate the effect of alcoholic extracts of Cissus quadrangularis (CQ), Cryptolepis buchanani (CB), and Sardinella longiceps (SL) either alone or in the combination (100 mg/kg) in the management of femur bone healing of Wistar albino rats for 8 weeks. After the period of treatment, femur bones were examined by using biochemical, radiographical, and histopathological studies.ResultBiochemical evaluation results reveal that there is a steep increase of serum calcium level in the experimental animals during the entire period of treatment which led to an adequate supply of serum calcium to the fractured bone for healing and increases the thickness of the femur bones soon compared to control group. It had been estimated by a calibrated ocular micrometer. Radiographical images of the bones also disclose that the complete bridging of fractured bone occurred in the experimental animals after the treatment of natural compound extracts. In addition to that, all the organs of animals were safe in the experimental animals during the entire study.ConclusionThe present study strongly recommended that these ethanolic extracts (CQCBSL) either alone or in the combination restoring the strength of the bone and reduced bone repairing period due to the rich content of calcium and other natural phytochemicals presents with them.Graphical abstract

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