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Evaluating sex hormones and cytokine profile in Egyptian females with relapsing-remitting multiple sclerosis

Authors
  • Talaat, Forayssa M.1
  • Abokrysha, Noha T.1
  • Labib, Dalia M.1
  • El Khateeb, Engy2
  • El Aziz, Ghada Hatem Abd1
  • 1 Cairo University, Neurology Department, Faculty of Medicine, Giza, Egypt , Giza (Egypt)
  • 2 Cairo University, Clinical Pathology Department, Faculty of Medicine, Giza, Egypt , Giza (Egypt)
Type
Published Article
Journal
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Publisher
Springer Berlin Heidelberg
Publication Date
Nov 03, 2018
Volume
54
Issue
1
Identifiers
DOI: 10.1186/s41983-018-0030-2
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundSexual dimorphism shown in multiple sclerosis suggests an interaction between immune system and sex hormones. The objective of this study is to determine the hormonal profile and serum cytokine levels in Egyptian female patients with relapsing-remitting MS (RRMS) compared with healthy controls and their associations with disease disability.MethodsThis study was conducted on 40 female patients with RRMS and 20 age-matched controls subjected to measurements of the hormonal profile (estrogen, testosterone) and cytokine levels (interleukin 10 and 4 and tumor necrosis factor alpha) and disability assessment using Expanded Disability Status Scale (EDSS).ResultsLevels of estrogen, testosterone, interleukin 10 and 4 (IL-10 and IL-4), and tumor necrosis factor alpha (TNF-α) were higher in patients compared to control with no statistically significant difference. Estrogen levels were positively correlated with interleukin 10 and interleukin 4 levels and negatively correlated with tumor necrosis factor alpha (TNF-α), but there was no statistically significant correlation between hormonal profile or cytokine profile (IL-10, IL-4, and TNF-α) and EDSS.ConclusionsIt is suggested that estrogen has an anti-inflammatory effect on cytokine milieu; therefore, it can be tried as a treatment option in multiple sclerosis.

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