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Evaluating reflexive saccades and UDPRS as markers of Deep Brain Stimulation and Best Medical Treatment improvements in Parkinson's disease patients: a prospective controlled study.

Authors
  • Szlufik, Stanisław1
  • Przybyszewski, Andrzej2
  • Dutkiewicz, Justyna3
  • Mandat, Tomasz4
  • Habela, Piotr2
  • Koziorowski, Dariusz3
  • 1 Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland. [email protected] , (Poland)
  • 2 Department of Informatics, Polish Japanese Academy of Information Technology, Warsaw, Poland. , (Japan)
  • 3 Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland. , (Poland)
  • 4 Department of Neurosurgery, Maria Sklodowska Curie Memorial Oncology Center, Warsaw, Poland. , (Poland)
Type
Published Article
Journal
Neurologia i neurochirurgia polska
Publication Date
Jan 01, 2019
Volume
53
Issue
5
Pages
341–347
Identifiers
DOI: 10.5603/PJNNS.a2019.0045
PMID: 31621890
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To date, there has been no clear evidence regarding the evaluation of saccades as a monitoring tool of motor impairment in Parkinson's disease (PD) Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) patients. The aim of this study was to evaluate the long-term impact of STN-DBS and pharmacological treatment on reflexive saccades' (RS) parameters and UPDRS alterations. The DBS group consisted of 20 PD patients who underwent bilateral STN-DBS. The Postoperative (POP) group consisted of 14 post-DBS patients. The Best Medical Therapy (BMT) group consisted of 20 patients on pharmacotherapy only. RS parameters and the UPDRS scale were measured during three visits in four phases of treatment (i.e. BMT-ON/OFF, DBS-ON/OFF). The significant UPDRS III and UPDRS. Total improvements were observed in all three study groups (p < 0.05), but RS latency improvement was stated only in the DBS group in the DBS-ON phase (p < 0.05). A significant correlation between RS latency increase and UPDRS III score worsening was found in all study groups, with the most evident effect in the UPDRS III ON phase (p < 0.05). RS parameters correlated with UPDRS III outcomes during the postoperative period in DBS-STN patients. Therefore, saccadic evaluation may be a good biomarker of the patient's response to surgical and/or pharmacological treatment.

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