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Evaluating QTc in patients with advanced Parkinson's disease: overcoming artifact.

Authors
  • Bloomfield, D M
Type
Published Article
Journal
Clinical Pharmacology & Therapeutics
Publisher
Wiley (Blackwell Publishing)
Publication Date
Apr 01, 2009
Volume
85
Issue
4
Pages
365–366
Identifiers
DOI: 10.1038/clpt.2008.153
PMID: 19295536
Source
Medline
License
Unknown

Abstract

Electrocardiograms (ECGs) in patients with Parkinson's disease are affected by artifacts related to muscle tremor. Malik et al. report methods used in QTc study in patients with Parkinson's disease that markedly reduce the noise and variance of QTc in a sample of ECGs that are undeniably difficult to interpret. This study adds significant experience and novel methods that have the potential to further enhance the evaluation of the effect of a drug on QTc.

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