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Evaluating the impact of a novel restricted reimbursement policy for quinolone antibiotics: A time series analysis

Authors
  • Manns, Braden1, 2, 3, 4
  • Laupland, Kevin1, 2
  • Tonelli, Marcello4, 5
  • Gao, Song4
  • Hemmelgarn, Brenda1, 2, 3, 4
  • 1 Departments of Medicine and Community Health Sciences, Calgary, Alberta, Canada , Calgary (Canada)
  • 2 The Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada , Calgary (Canada)
  • 3 University of Calgary, Alberta Kidney Disease Network, Calgary, Alberta, Canada , Calgary (Canada)
  • 4 Division of Nephrology, Department of Medicine, Alberta, Canada , Alberta (Canada)
  • 5 University of Alberta, Edmonton, Alberta, Canada , Edmonton (Canada)
Type
Published Article
Journal
BMC Health Services Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Aug 30, 2012
Volume
12
Issue
1
Identifiers
DOI: 10.1186/1472-6963-12-290
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundPublicly-funded drug plans often use prior authorization policies to limit drug prescribing. To guide physician prescribing of a class of antibiotics with broad antimicrobial activity (quinolone antibiotics) in accordance with new prescribing guidelines, Alberta’s provincial health ministry implemented a new mechanism for formulary restriction entitled the optional special authorization (OSA) program. We conducted an observational study to determine the impact of this new formulary restriction policy on antimicrobial prescription rates as well as any clinical consequences.MethodsQuinolone antibiotic use, and adherence with quinolone prescribing guidelines, was assessed before and after implementation of the OSA program in patients with common outpatient infections using an administrative data cohort and a chart review cohort, respectively. At the same time this policy was implemented to limit quinolone prescribing, two new quinolone antibiotics were added to the formulary. Using administrative data, we analysed a total of 397,534 unique index visits with regard to overall antibiotic utilization, and through chart review, we analysed 1681 charts of patients with infections of interest to determine the indications for quinolone usage.ResultsUsing segmented regression models adjusting for age, sex and physician enrollment in the OSA program, there was no statistically significant change in the monthly rate of all quinolone use (−3.5 (95% CI −5.5, 1.4) prescriptions per 1000 index visits) following implementation of the OSA program (p = 0.74). There was a significant level change in the rate of quinolone antibiotic use for urinary tract infection (−33.6 (95% CI: -23.8, -43.4) prescriptions and upper respiratory tract infection (−16.1 (95%CI: -11.6, -20.6) prescriptions per 1000 index visits. Among quinolone prescriptions identified on chart review, 42.5% and 58.5% were consistent with formulary guidelines before and after the implementation of the OSA program, respectively (p = 0.002). There was no change in hospitalization, mortality or use of physician services after implementation of the OSA program.ConclusionsDespite the addition of two new quinolone antibiotics to the formulary, we found that there was no change in the use of quinolones after implementation of a new formulary restriction policy for outpatients with common outpatient infections.

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