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European experience with flurbiprofen. A new analgesic/anti-inflammatory agent.

Authors
  • Buchanan, W W
  • Kassam, Y B
Type
Published Article
Journal
The American Journal of Medicine
Publisher
Elsevier
Publication Date
Mar 24, 1986
Volume
80
Issue
3A
Pages
145–152
Identifiers
PMID: 3963022
Source
Medline
License
Unknown

Abstract

Numerous European clinical trials begun more than 12 years ago have clearly demonstrated flurbiprofen's safety and efficacy as an analgesic, anti-inflammatory, and antipyretic agent. In preclinical studies, flurbiprofen was at least as potent as indomethacin, and approximately 200 times more potent than aspirin. For patients with rheumatoid arthritis, a review of several trials found flurbiprofen often superior to aspirin and naproxen, and equivalent to indomethacin and ibuprofen in efficacy. Acetaminophen appeared no more effective than placebo for patients with rheumatoid arthritis. For patients with ankylosing spondylitis, flurbiprofen was also shown to be equivalent or superior to indomethacin and phenylbutazone. For patients with osteoarthritis of the peripheral joints, spine, hip, and knee, flurbiprofen was again found equal to ibuprofen, diclofenac, indomethacin, and naproxen. Side effects with flurbiprofen were few and predominantly related to the gastrointestinal tract.

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